研究業績　Publications

筆頭またはCorrespondence　First Author or Corresponding Author

68. Suzukawa R, Mandai S (Corresponding author), Nakano Y, Inaba S, Matsuki H, Mori Y, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Rai T, Fushimi K, Uchida S. Perioperative Antihypertensive Medications and Effects on Functional Decline and Mortality in Non-cardiac Surgery. European Heart Journal Open. 5(4):oeaf096, 2025. https://doi.org/10.1093/ehjopen/oeaf096
69. Nakano Y, Mandai S (Corresponding author), Mori Y, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Fushimi K, Uchida S. Cognitive Impairment and Physical Dysfunction Associated With Unplanned Dialysis Initiation. Kidney International Reports. 10(7):2424-2435, 2025. https://doi.org/10.1016/j.ekir.2025.04.018
70. Suzukawa R, Mandai S (Corresponding author), Hashimoto H, Shikuma S, Kimura M, Toma H, Sakaguchi Y, Shiraishi S, Toshima N, Hoshino M, Kimura M, Ota J, Horiuchi S, Adachi S, Uchida S. Response Letter to Comment on: The Effect of Antihypertensive Therapy on Skeletal Muscle Mass and Bone Mineral Density in Patients With End-Stage Kidney Disease. J Ren Nutr. 35(4):560-561, 2025. https://doi.org/10.1053/j.jrn.2025.03.003
71. Nakano Y, Mandai S (Corresponding author), Mori Y, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Fushimi K, Uchida S. Nationwide mortality following acute type B aortic dissection and the survival advantage of obesity among dialysis patients in Japan. J Nephrol. 38(2):503-510, 2025. http://doi.org/10.1007/s40620-024-02147-8
72. Hashimoto H, Mandai S (Corresponding author), Shikuma S, Kimura M, Toma H, Sakaguchi Y, Shiraishi S, Toshima N, Hoshino M, Kimura M, Ota J, Horiuchi S, Adachi S, Uchida S. The Effect of Antihypertensive Therapy on Skeletal Muscle Mass and Bone Mineral Density in Patients With End-Stage Kidney Disease. J Ren Nutr. 34(3):223-234, 2024. https://doi.org/10.1053/j.jrn.2023.10.008
73. Nakano Y, Mandai S (Corresponding author), Naito S, Fujiki T, Mori Y, Ando F, Mori T, Susa K, Iimori S, Sohara E, Uchida S. Effect of osteosarcopenia on longitudinal mortality risk and chronic kidney disease progression in older adults. Bone. 179:116975, 2024. https://doi.org/10.1016/j.bone.2023.116975
74. Ikenouchi K, Takahashi D, Mandai S (Corresponding author), Watada M, Koyama S, Hoshino M, Takahashi N, Shoda W, Kuyama T, Mori Y, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Fushimi K, Uchida S. Impact of COVID-19 versus other pneumonia on in-hospital mortality and functional decline among Japanese dialysis patients: a retrospective cohort study. Sci Rep. 14(1):5177, 2024. https://doi.org/10.1038/s41598-024-55697-z
75. Hashimoto H, Mandai S, Shikuma S, Kimura M, Toma H, Sakaguchi Y, Kimura M, Ota J, Chiba Y, Sakai K, Horiuchi S, Adachi S, Uchida S. Hypoxia-inducible factor prolyl hydroxylase domain inhibitors may mitigate loss of skeletal muscle mass in haemodialysis patients. JCSM Communications. 7:6–16, 2024. https://doi.org/10.1002/rco2.87
76. Nakano Y, Mandai S (Corresponding author), Takahashi D, Ikenouchi K, Mori Y, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Fushimi K, Uchida S. Sex disparities in the risk of urgent dialysis following acute aortic dissections in Japan. Sex disparities in the risk of urgent dialysis following acute aortic dissections in Japan. iScience. 27(8):110577, 2024. https://doi.org/10.1016/j.isci.2024.110577
77. Hara M, Mandai S (Corresponding author), Mori T, Maejima Y, Uchida S. Takayasu arteritis manifesting as acute kidney injury and congestion due to renal artery stenosis and myocarditis: a case report. Eur Heart J Case Rep. 8(8):ytae347, 2024. https://doi.org/10.1093/ehjcr/ytae347
78. Matsuki H, Genma T, Mandai S (Corresponding author), Fujiki T, Mori Y, Ando F, Susa K, Iimori S, Naito S, Sohara E, Rai T, Fushimi K, Uchida S. National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 2019. Hypertension. 80(12):2591–2600, 2023. https://doi.org/10.1161/HYPERTENSIONAHA.123.21880
79. Koide T, Mandai S (Corresponding author, equal contribution), Kitaoka R, Matsuki H, Chiga M, Yamamoto K, Yoshioka K, Yagi Y, Suzuki S, Fujiki T, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Rai T, Yokota T, Uchida S. Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circulation Research. 132(4):415–431, 2023. https://doi.org/10.1161/CIRCRESAHA.122.321939
80. Matsuki H, Mandai S (Corresponding author), Shiwaku H, Koide T, Takahashi N, Yanagi T, Inaba S, Ida S, Fujiki T, Mori Y, Ando F, Mori T, Susa K, Iimori S, Sohara E, Takahashi H, Uchida S. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging (Albany NY). 15(20):10972–10995, 2023. https://doi.org/10.18632/aging.205164
81. Mandai S (Corresponding author), Koide T, Fujiki T, Mori Y, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T. Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study. JMA Journal. 6(4):404–413, 2023. https://doi.org/10.31662/jmaj.2022-0188
82. Nakano Y, Mandai S (Corresponding author), Genma T, Akagi Y, Fujiki T, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T. Nationwide mortality associated with perioperative acute dialysis requirement in major surgeries. International Journal of Surgery. 104:106816, 2022. https://doi.org/10.1016/j.ijsu.2022.106816
83. Mandai S (Corresponding author), Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T. Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study. PLoS One. 16(11):e0258846, 2021. https://doi.org/10.1371/journal.pone.0258846
84. Hashimoto H, Shikuma S, Mandai S (Corresponding author), Adachi S, Uchida S. Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients. Scientific Reports. 11:1648, 2021. https://doi.org/10.1038/s41598-021-81287-4
85. Mandai S, Yamada T, Uchihara T, Iida T, Ito T, Sato H, Sato K, Chida Y, Hirokawa K, Noda Y. Severe Dialysis-Related Amyloidosis Spared the Brain: An Autopsy Case of a Patient Receiving Hemodialysis for 41 Years. Journal of Neuropathology and Experimental Neurology. 80(10):997–999, 2021. https://doi.org/10.1093/jnen/nlab022
86. Mandai S, Sato H, Iimori S, Naito S, Tanaka H, Ando F, Susa K, Isobe K, Mori T, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T. Nationwide In-Hospital Mortality Following Major Fractures among Hemodialysis Patients and the General Population: An Observational Cohort Study. Bone. 31:115122, 2020. https://doi.org/10.1016/j.bone.2019.115122
87. Noda S, Mandai S (Corresponding author), Oda T, Shinoto T, Sato H, Sato K, Hirokawa K, Noda Y, Uchida S. Asymptomatic sinusitis as an origin of infection-related glomerulonephritis manifesting steroid-resistant nephrotic syndrome: A case report. Medicine. 99:e20572, 2020. https://doi.org/10.1097/MD.0000000000020572
88. Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S. WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4. Scientific Reports. 8:9101, 2018. https://doi.org/10.1038/s41598-018-27414-0
89. Mandai S, Sato H, Iimori S, Naito S, Mori T, Takahashi D, Zeniya M, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T. Dialysis case volume associated with in-hospital mortality in maintenance dialysis patients. Kidney International Reports. 3(2):356–363, 2017. https://doi.org/10.1016/j.ekir.2017.10.015
90. Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, Ando F, Mori Y, Takahashi D, Yoshizaki Y, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Furuichi Y, Fujii NL, Sohara E, Rai T, Uchida S. Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. Scientific Reports. 7:46369, 2017. https://doi.org/10.1038/srep46369
91. Mandai S, Kanda E, Iimori S, Naito S, Noda Y, Kikuchi H, Akazawa M, Oi K, Toda T, Sohara E, Okado T, Sasaki S, Rai T, Uchida S. Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study. Clinical and Experimental Nephrology. 21:104–111, 2017. http://doi.org/10.1007/s10157-016-1261-0
92. Takehara E, Mandai S (Corresponding author), Shikuma S, Akita W, Chiga M, Mori T, Oda T, Kuwahara M, Uchida S. Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation. Internal Medicine. 56:811–817, 2017. https://doi.org/10.2169/internalmedicine.56.7778
93. Mandai S, Mori T, Sohara E, Rai T, Uchida S. Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines With the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 System. Hypertension. 66:1199–1206, 2015. https://doi.org/10.1161/HYPERTENSIONAHA.115.05872
94. Mandai S (Corresponding author), Kasagi Y, Kusaka K, Shikuma S, Akita W, Kuwahara M. Helicobacter cinaedi kidney cyst infection and bacteremia in a patient with autosomal dominant polycystic kidney disease. Journal of Infection and Chemotherapy. 20:732–734, 2014. https://doi.org/10.1016/j.jiac.2014.07.012
95. Mandai S (Corresponding author), Kuwahara M, Kasagi Y, Kusaka K, Tanaka T, Shikuma S, Akita W, Sasaki S. Lower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study. BMC Nephrology. 14:276, 2013. https://doi.org/10.1186/1471-2369-14-276
96. Mandai S (Corresponding author), Kanda E, Arai Y, Hirasawa S, Hirai T, Aki S, Inaba N, Aoyagi M, Tanaka H, Ikeda T, Tamura T, Sasaki S. Anti-centromere antibody is an independent risk factor for chronic kidney disease in patients with primary biliary cirrhosis. Clinical and Experimental Nephrology. 17:405–410, 2013. http://doi.org/10.1007/s10157-012-0724-1
97. Mandai S (Corresponding author), Aoyagi M, Nagahama K, Arai Y, Hirasawa S, Aki S, Inaba N, Tanaka H, Tsuura Y, Tamura T, Sasaki S. Post-Staphylococcal infection Henoch-Schönlein purpura nephritis: a case report and review of the literature. Renal Failure. 35:869–874, 2013. https://doi.org/10.3109/0886022X.2013.794703
98. Mandai S (Corresponding author), Arai Y, Hirasawa S, Hirai T, Aki S, Inaba N, Aoyagi M, Tanaka H, Tamura T, Sasaki S. Anti-centromere Antibody-positive Subjects Presenting with Hypertensive Emergency and Renal Dysfunction in the Absence of Skin Manifestations: A Variant of Systemic Sclerosis or a Novel Entity? Internal Medicine. 51:1567–1572, 2012. https://doi.org/10.2169/internalmedicine.51.6924
99. Mandai S (Corresponding author), Nagahama K, Tsuura Y, Hirai T, Yoshioka W, Takahashi D, Aki S, Aoyagi M, Tanaka H, Tamura T. Recovery of Renal Function in a Dialysis-dependent Patient with Microscopic Polyangiitis and both Myeloperoxidase Anti-neutrophil Cytoplasmic Antibodies and Anti-glomerular Basement Membrane Antibodies. Internal Medicine. 50:1599–1603, 2011. https://doi.org/10.2169/internalmedicine.50.4939

共著　Co-author

1. Kawamoto R, Mori T, Chiga M, Fujimaru T, Nanamatsu A, Fujiki T, Mori Y, Mandai S, Ando F, Susa K, Rai T, Sohara E, Uchida S. Importance of family history and health checkup for school-aged children for type IV collagen-associated nephropathy in hereditary kidney disease. J Nephrol. 2025 Aug 2. http://doi.org/10.1007/s40620-025-02355-w
2. Nakao Y, Mori Y, Kunieda J, Taguchi T, Mori K, Yamamura A, Naito S, Ando F, Mandai S, Iimori S, Susa K, Mori T, Ohashi K, Sohara E, Uchida S. Successful Remission of Nephrotic Syndrome Caused by IgA Nephropathy with Membranoproliferative Glomerulonephritis-pattern Lesion Treated by Cyclosporine and Oral Corticosteroids. Intern Med. 2025 Jul 10. http://doi.org/10.2169/internalmedicine.5526-25
3. Mori M, Mori Y, Nakao Y, Mandai S, Fujiki T, Kikuchi H, Ando F, Susa K, Mori T, Waseda Y, Yoshida S, Fujii Y, Sohara E, Uchida S. Development of Adult Renal Tubular Organoids from Different Human Individuals in a Single Medium. JMA J. 8(1):191-197, 2025. http://doi.org/10.31662/jmaj.2024-0244
4. Morimoto N, Shioji S, Akagi Y, Fujiki T, Mandai S, Ando F, Mori T, Susa K, Naito S, Sohara E, Anzai T, Takahashi K, Akita W, Ohta A, Uchida S, Iimori S. Author’s Reply: “Associations Between Dietary Potassium Intake From Different Food Sources and Hyperkalemia in Patients With Chronic Kidney Disease”. J Ren Nutr. S1051-2276(25)00099-8, 2025. https://doi.org/10.1053/j.jrn.2025.05.005
5. Mori T, Fujimaru T, Liu C, Patterson K, Yamamoto K, Suzuki T, Chiga M, Sekine A, Ubara Y, Miller DE, Zalusky MPG, Mandai S, Ando F, Mori Y, Kikuchi H, Susa K; University of Washington Center for Rare Disease Research; Chong JX, Bamshad MJ, Tan YQ, Zhang F, Uchida S, Sohara E. CFAP47 is Implicated in X-Linked Polycystic Kidney Disease. Kidney Int Rep. 9(12):3580-3591, 2024. http://doi.org/10.1016/j.ekir.2024.09.013
6. Yanagi T, Kikuchi H, Takeuchi K, Susa K, Mori T, Chiga M, Yamamoto K, Furukawa A, Kanazawa T, Kato Y, Takahashi N, Suzuki T, Mori Y, Carter BC, Mori M, Nakano Y, Fujiki T, Hara Y, Suzuki S, Ando F, Mandai S, Honda S, Torii S, Shimizu S, Tanaka H, Fujii Y, Rai T, Uchida S, Sohara E. ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease. Kidney Int. 106(5):887-906, 2024. http://doi.org/10.1016/j.kint.2024.08.024
7. Morimoto N, Shioji S, Akagi Y, Fujiki T, Mandai S, Ando F, Mori T, Susa K, Naito S, Sohara E, Anzai T, Takahashi K, Akita W, Ohta A, Uchida S, Iimori S. Associations Between Dietary Potassium Intake From Different Food Sources and Hyperkalemia in Patients With Chronic Kidney Disease. J Ren Nutr. 34(6):519-529, 2024. http://doi.org/10.1053/j.jrn.2024.03.008
8. Fujimaru T, Mori T, Sekine A, Chiga M, Mandai S, Kikuchi H, Mori Y, Hara Y, Fujiki T, Ando F, Susa K, Iimori S, Naito S, Hanazawa R, Hirakawa A, Mochizuki T, Suwabe T, Ubara Y, Uchida S, Sohara E. Importance of IFT140 in Patients with Polycystic Kidney Disease Without a Family History. Kidney Int Rep. 9(9):2685-2694, 2024. http://doi.org/10.1016/j.ekir.2024.06.021
9. Hata M, Mori T, Hirose Y, Nishida Y, Mandai S, Ando F, Susa K, Iimori S, Naito S, Sohara E, Rai T, Taguchi T, Tomii S, Ohashi K, Uchida S. A case of unexpected diagnosis of fibronectin glomerulopathy with histological features of membranoproliferative glomerulonephritis. BMC Nephrol. 25(1):25, 2024. http://doi.org/10.1186/s12882-024-03456-7
10. Fujimaru T, Mori T, Chiga M, Mandai S, Kikuchi H, Ando F, Mori Y, Susa K, Nakano Y, Shoji T, Fukudome Y, Inaba N, Kitamura K, Nakanishi T, Uchida K, Kimura T, Tamura T, Ozawa K, Uchida S, Sohara E. Genetic Diagnosis of Adult Hemodialysis Patients With Unknown Etiology. Kidney Int Rep. 9(4):994-1004, 2024. http://doi.org/10.1016/j.ekir.2024.01.027
11. Yanagawa H, Hara Y, Ando F, Suzuki S, Fujiki T, Oikawa D, Yui N, Mandai S, Mori Y, Susa K, Mori T, Sohara E, Tokunaga F, Uchida S. LRBA signalosomes activate vasopressin-induced AQP2 trafficking at recycling endosomes. J Physiol. 601(23):5437-5451, 2023. http://doi.org/10.1113/JP285188
12. Suzuki S, Ando F, Kitagawa S, Hara Y, Fujiki T, Mandai S, Susa K, Mori T, Sohara E, Rai T, Uchida S. ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Commun Biol. 6(1):29, 2023. http://doi.org/10.1038/s42003-023-04416-x
13. Morimoto N, Mori T, Shioji S, Watanabe H, Sakai K, Mori K, Yamamura A, Hanioka A, Akagi Y, Fujiki T, Mandai S, Mori Y, Ando F, Susa K, Iimori S, Naito S, Sohara E, Uchida S. Thrombocytopenia during avacopan administration: A case report. Int J Rheum Dis. 26(8):1603-1607, 2023. http://doi.org/10.1111/1756-185X.14645
14. Morimoto N, Mori T, Shioji S, Taguchi T, Watanabe H, Sakai K, Mori K, Yamamura A, Hanioka A, Akagi Y, Fujiki T, Mandai S, Mori Y, Ando F, Susa K, Iimori S, Naito S, Sohara E, Ohashi K, Uchida S. Rapidly progressive IgA nephropathy with membranoproliferative glomerulonephritis-like lesions in an elderly man following the third dose of an mRNA COVID-19 vaccine: a case report. BMC Nephrol. 24(1):108, 2023. http://doi.org/10.1186/s12882-023-03169-3
15. Yanagi T, Kikuchi H, Susa K, Takahashi N, Bamba H, Suzuki T, Nakano Y, Fujiki T, Mori Y, Ando F, Mandai S, Mori T, Takeuchi K, Honda S, Torii S, Shimizu S, Rai T, Uchida S, Sohara E. Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. Genes Cells. 28(1):5-14, 2023. http://doi.org/10.1111/gtc.12989
16. Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S. LRBA is essential for urinary concentration and body water homeostasis. Proc Natl Acad Sci U S A. 119(30):e2202125119, 2022. http://doi.org/10.1073/pnas.2202125119
17. Nanamatsu A, Mori T, Ando F, Furusho T, Mandai S, Susa K, Sohara E, Rai T, Uchida S. Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A). Hypertension. 77(6):1953, 2021. http://doi.org/10.1161/HYPERTENSIONAHA.121.17127
18. Mori T, Chiga M, Fujimaru T, Kawamoto R, Mandai S, Nanamatsu A, Nomura M, Ando F, Susa K, Sohara E, Rai T, Uchida S. Phenotypic differences of mutation-negative cases in Gitelman syndrome clinically diagnosed in adulthood. Hum Mutat. 42(3):300–9, 2021. http://doi.org/10.1002/humu.24159
19. Arai Y, Asano K, Mandai S, Ando F, Susa K, Mori T, Nomura N, Rai T, Tanaka M, Uchida S, Sohara E. WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages. Biochem Biophys Res Commun. 533(4):1290–7, 2020. http://doi.org/10.1016/j.bbrc.2020.10.007
20. Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S. Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease. Kidney Int. 97(4):713-727, 2020. http://doi.org/10.1016/j.kint.2019.11.021
21. Sekine A, Hoshino J, Fujimaru T, Suwabe T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y. Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 51:745–51, 2020. http://doi.org/10.1159/000509817
22. Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease. Kidney Int. 95(1):123-137, 2019. http://doi.org/10.1016/j.kint.2018.08.030
23. Sekine A, Fujimaru T, Hoshino J, Suwabe T, Oguro M, Mizuno H, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y. Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History. Am J Nephrol. 49(3):233-240, 2019. http://doi.org/10.1159/000497444
24. Nomura N, Shoda W, Wang Y, Mandai S, Furusho T, Takahashi D, Zeniya M, Sohara E, Rai E, Uchida S. Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney. Biosci Rep. 38(1):BSR20171243, 2018. http://doi.org/10.1042/BSR20171243
25. Fujimaru T, Mori T, Sekine A, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Iimori S, Naito S, Okado T, Rai T, Hoshino J, Ubara Y, Uchida S, Sohara E. Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease. Clin Genet. 94(1):125–131, 2018. https://doi.org/10.1111/cge.13249
26. Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E. Affiliations ExpandKLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. Mol Cell Biol. 37:e00508-16, 2017. http://doi.org/10.1128/MCB.00508-16
27. Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Inoue I, Shinichi Uchida 3. Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel. Clin Exp Nephrol. 21:63-75, 2017. https://doi.org/10.1007/s10157-016-1252-1-016-1252-1
28. Kikuchi H, Kanda E, Mandai S, Akazawa M, Iimori S, Oi K, Naito S, Noda Y, Toda T, Tamura T, Sasaki S, Sohara E, Okado T, Rai T, Uchida S. Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology (CKD-ROUTE) study. Clin Exp Nephrol. 21:55-62, 2017. http://doi.org/10.1007/s10157-016-1251-2
29. Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S, Sohara E. Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells. Sci Rep. 7:46580, 2017. http://doi.org/10.1038/srep46580
30. Yoshizaki Y, Mori T, Ishigami-Yuasa M, Kikuchi E, Takahashi D, Zeniya M, Nomura N, Mori Y, Araki Y, Ando F, Mandai S, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Kagechika H, Rai T, Uchida S, Sohara E. Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy. Sci Rep. 7:3945, 2017. http://doi.org/10.1038/s41598-017-04233-3
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その他プレスリリースなど　Press Releases and Other Announcements

2025年

非心臓手術における予後を改善する降圧薬を同定か
ACE阻害薬／ARBの継続使用が死亡・身体機能低下リスクの低減と関連
European Heart Journal Open, 2025年08月
非心臓手術における予後を改善する降圧薬を同定か | Science Tokyo – 東京科学大学

高齢者の認知・身体機能低下が予期せぬ透析開始リスクと医療費増大に影響
全国データによる大規模解析が示す、透析準備の計画的介入と多職種連携の必要性
Kidney International Reports, 2025年05月
高齢者の認知・身体機能低下が予期せぬ透析開始リスクと医療費増大に影響 | Science Tokyo – 東京科学大学

2024年

急性大動脈解離後の緊急透析リスクに男女差
女性では虚血性の急性腎障害が軽症化しやすい可能性
iScience, 2024年08月
「 急性大動脈解離後の緊急透析リスクに男女差 」【萬代新太郎 テニュアトラック准教授、内田信一 教授】 | Science Tokyo 旧・東京医科歯科大学

2023年

The silent killer gets louder as high blood pressure risks trend upward
AAAS EurekAlert! The Global Source for Science News, 2023年12月
The silent killer gets louder as high blood pressure risks trend upward | EurekAlert!

慢性腎臓病による“血液脳関門の機能障害”と”タウタンパク質の不溶化”を発見
認知症のメカニズム解明に貢献しうる知見
Aging (Albany NY), 2023年10月
「慢性腎臓病による“血液脳関門の機能障害”と”タウタンパク質の不溶化”を発見」【内田信一 教授、萬代新太郎 助教】 | Science Tokyo 旧・東京医科歯科大学

悪性高血圧の予後が判明
10年間の急性高血圧症の死亡・緊急透析リスクとそのリスク因子が明らかに
Hypertension, 2023年10月
「悪性高血圧の予後が判明」【内田信一 教授、萬代新太郎 助教】 | Science Tokyo 旧・東京医科歯科大学

Tokyo Medical and Dental University finds vascular calcification in chronic kidney disease caused by circulating extracellular vesicles — Arteriosclerosis can be suppressed with existing drugs
Science Japan by JST, 2023年06月
Tokyo Medical and Dental University finds vascular calcification in chronic kidney disease caused by circulating extracellular vesicles — Arteriosclerosis can be suppressed with existing drugs | News | Science Japan

Link between chronic kidney disease and cardiovascular disease explained
AAAS EurekAlert! The Global Source for Science News, 2023年03月
Link between chronic kidney disease and cardiovascular disease explained | EurekAlert!

慢性腎臓病において血管石灰化を引き起こす悪玉メッセージ物質を発見
循環細胞外小胞を標的とした慢性腎臓病、心血管病の新たな治療薬の開発に期待
Circulation Research, 2023年02月
「慢性腎臓病において血管石灰化を引き起こす悪玉メッセージ物質を発見」【萬代新太郎 助教】 | Science Tokyo 旧・東京医科歯科大学

2022年

Urgent dialysis during hospitalization for surgery predicts poor outcomes
AAAS EurekAlert! The Global Source for Science News, 2022年09月
Urgent dialysis during hospitalization for surgery predicts poor outcomes | EurekAlert!

全国規模の解析で明らかとなった 周術期の透析開始の予後への影響
手術前後の透析開始判断、治療成績の向上に貢献し得る成果
International Journal of Surgery, 2022年08月
「全国規模の解析で明らかとなった 周術期の透析開始の予後への影響」【萬代新太郎 助教】 | Science Tokyo 旧・東京医科歯科大学

2021年

全国規模の入院データ解析により慢性腎臓病（CKD）の複雑病態を可視化
CKDに対して早期から集学的診療を行う重要性を示唆
PLoS One, 2021年11月
「全国規模の入院データ解析により慢性腎臓病（CKD）の複雑病態を可視化」【頼建光 教授、萬代新太郎 助教】 | Science Tokyo 旧・東京医科歯科大学

2017年骨格筋の形成・肥大にNa-K-Cl共輸送体（NKCC）が関与
ループ利尿薬がサルコペニアに関与する可能性を示唆
Scientific Reports, 2017年04月